Monday, June 30, 2008
Saturday, June 28, 2008
Friday, June 27, 2008
- "By combining our resources, we're able to proceed with what is the world's largest and most thorough evaluation of colon cancer pathology and metabolic risk factors ever performed in the history of medicine," said Dr. Dayan Goodenowe, CEO of the Saskatoon company.
Speaking at a Wednesday news conference, he said Phenomenome's research has indicated 90 per cent of people who have colon cancer have a metabolic deficiency. Based on six years of research that involved more than 1,000 people worldwide, the company has developed a highly validated blood test to identify who has the deficiency.
The two-year trial will begin at the Pasqua and General hospitals [in Regina] and will involve 5,000 patients".
- Robert Hilsden, MD, from the University of Calgary is conducting an investigator sponsored clinical trial using Phenomenome's gTA test. This prospective cohort study will be conducted at the Forzani Charities Colon Cancer Screening Centre (CCSC) in Calgary. The study protocol has a two arm design to evaluate average and moderately high risk subjects with no known colon pathology and a smaller sub-study of CRC positive subjects.
The primary aim of the first component of the study is to assess the diagnostic accuracy of the gTA test in detecting CRC in asymptomatic persons scheduled for a screening colonoscopy based on fecal occult blood results. The second component of the study will focus on the gTA levels of CRC positive subject's pre and post-surgery to determine effects of tumor resection. All study subjects will be followed longitudinally for three years with additional gTA tests and colonoscopies based on the initial results. The goal is to enroll 1300 subject in the first arm of the study and 150 CRC-positive subjects in the second arm of the study.
This study is scheduled to begin in 2008.
Thursday, June 26, 2008
Tuesday, June 24, 2008
from Pat Clifford (2006), Embracing Brings You Back, Coteau Books
Returning home from France,
their throats and lungs burned out, spent soldiers share
my life: bone-cracked exhaustion, baldness, retching, mouth sores and the curse
of cramping diarrhea.
It took some smart American nerve gas scientists to put
two and two together over coffee, I imagine, brewed on Bunsen flames.
Guts and hair grow fast. As do cancer cells, so: why not? When we’re finished
with the Germans we can hit that other fucking shit, no?
My television shouts Iraq but I don’t need to travel half a world
away for the chemistry of mass destruction. My only hope
for survival squats in the sterile fluorescence of the Cancer Day
Care unit ten kilometers from my home, waiting.
Monday, June 23, 2008
Sunday, June 22, 2008
The intestinal tract did not evolve to compensate for mechanical bowel obstruction caused by an immobile, fixed lesion such as cancer. The physiologic changes that arise with obstruction would be adaptive to reversible forms of bowel obstruction that may have occurred for our ancient ancestors, but they are maladaptive for patients with cancer. Similarly, kidneys demonstrate a maladaptive response to heart failure. Decreased renal perfusion is sensed as dehydration. Fluid is retained to compensate when, in fact, the patient is drowning. We adjust for this by "overruling" the kidneys, telling them to get rid of salt and water and not hold on to them. The kidneys can be mistaken. What "misunderstanding" arises in bowel obstruction?
Imagine that you have been very hungry. Your tribe finally hunts down a mastodon, and it is time for a feast. You gorge yourself, eating great chunks of meat and causing a temporary obstruction. Your body would respond in the following way.
1. Mechanoreceptors and chemoreceptors would be stimulated by the distention caused by the large build-up of food proximal to the blockage. These receptors would tell your brain to stop eating.
- 2. The intestine proximal to the blockage would begin hypersecreting fluid, trying to flood the system and wash the intestinal contents downstream.
- 3. Intestinal motility would increase, further trying to push contents downstream and causing cramping.
- With luck, you would live to hunt another day. While this approach works well for ingested mastodons, it works poorly for malignant bowel obstruction.